{
  "count": 24,
  "items": [
    {
      "id": "bg-aging-reversal-mechanisms",
      "title": "Mechanistic understanding and reversal of biological aging",
      "source_domain": "geroscience",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-aging-reversal-mechanisms.yaml"
    },
    {
      "id": "bg-alzheimers-mechanism",
      "title": "Disease-Modifying Alzheimer's Therapy — Resolving the Causal Mechanism",
      "source_domain": "neuroscience",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-alzheimers-mechanism.yaml"
    },
    {
      "id": "bg-antibiotic-resistance-crisis",
      "title": "New Antibiotic Classes and Alternative Strategies to Overcome Antimicrobial Resistance",
      "source_domain": "microbiology",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-antibiotic-resistance-crisis.yaml"
    },
    {
      "id": "bg-carbon-direct-air-capture",
      "title": "Economically Viable Direct Air Capture of CO2",
      "source_domain": "chemistry",
      "current_trl": 7,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-carbon-direct-air-capture.yaml"
    },
    {
      "id": "bg-consciousness-neural-correlates",
      "title": "Identifying the neural correlates of consciousness and subjective experience",
      "source_domain": "neuroscience",
      "current_trl": 2,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-consciousness-neural-correlates.yaml"
    },
    {
      "id": "bg-controlled-nuclear-fusion-power",
      "title": "Net energy gain controlled nuclear fusion at commercial scale",
      "source_domain": "plasma-physics",
      "current_trl": 4,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-controlled-nuclear-fusion-power.yaml"
    },
    {
      "id": "bg-de-novo-protein-design",
      "title": "Rational de novo protein design for arbitrary function",
      "source_domain": "biochemistry",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-de-novo-protein-design.yaml"
    },
    {
      "id": "bg-fusion-energy-ignition",
      "title": "Commercial Fusion Energy — From NIF Ignition to Grid-Scale Power",
      "source_domain": "plasma-physics",
      "current_trl": 4,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-fusion-energy-ignition.yaml"
    },
    {
      "id": "bg-hydrogen-water-splitting",
      "title": "Low-Temperature Electrochemical Water Splitting for Green Hydrogen",
      "source_domain": "electrochemistry",
      "current_trl": 4,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-hydrogen-water-splitting.yaml"
    },
    {
      "id": "bg-mrna-programmable-medicine",
      "title": "Programmable mRNA Therapeutics Beyond COVID Vaccines",
      "source_domain": "molecular-biology",
      "current_trl": 6,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-mrna-programmable-medicine.yaml"
    },
    {
      "id": "bg-neural-interface-bandwidth",
      "title": "High-Bandwidth Brain-Computer Interfaces for Restoring and Augmenting Neural Function",
      "source_domain": "neuroscience",
      "current_trl": 5,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-neural-interface-bandwidth.yaml"
    },
    {
      "id": "bg-neuromorphic-computing-at-scale",
      "title": "Neuromorphic computing at scale — brain-matched energy efficiency for AI inference",
      "source_domain": "computer-science",
      "current_trl": 3,
      "world_reshaping_potential": "significant",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-neuromorphic-computing-at-scale.yaml"
    },
    {
      "id": "bg-ocean-plastic-remediation",
      "title": "Scalable removal and degradation of ocean microplastics",
      "source_domain": "environmental-science",
      "current_trl": 2,
      "world_reshaping_potential": "significant",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-ocean-plastic-remediation.yaml"
    },
    {
      "id": "bg-photosynthesis-efficiency",
      "title": "Artificial and Enhanced Photosynthesis — Closing the Efficiency Gap from 1-2% to Theoretical Maximum",
      "source_domain": "biochemistry",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-photosynthesis-efficiency.yaml"
    },
    {
      "id": "bg-post-treatment-lyme-disease-syndrome",
      "title": "Post-Treatment Lyme Disease Syndrome (PTLDS) — Mechanism and Cure",
      "source_domain": "immunology",
      "current_trl": 3,
      "world_reshaping_potential": "significant",
      "blocking_gap_count": 5,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-post-treatment-lyme-disease-syndrome.yaml"
    },
    {
      "id": "bg-programmable-matter",
      "title": "Programmable matter — reconfigurable materials that change shape and function on demand",
      "source_domain": "materials-science",
      "current_trl": 2,
      "world_reshaping_potential": "significant",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-programmable-matter.yaml"
    },
    {
      "id": "bg-quantum-computing-fault-tolerant",
      "title": "Fault-Tolerant Quantum Computation at Practical Scale",
      "source_domain": "quantum-physics",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-quantum-computing-fault-tolerant.yaml"
    },
    {
      "id": "bg-room-temperature-superconductivity",
      "title": "Ambient-Pressure Room-Temperature Superconductivity",
      "source_domain": "condensed-matter-physics",
      "current_trl": 2,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-room-temperature-superconductivity.yaml"
    },
    {
      "id": "bg-scalable-quantum-computing",
      "title": "Fault-tolerant scalable quantum computing with more than one million logical qubits",
      "source_domain": "quantum-computing",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-scalable-quantum-computing.yaml"
    },
    {
      "id": "bg-scientific-knowledge-overload",
      "title": "Cross-Disciplinary Scientific Discovery — Systematic Infrastructure for Cross-Domain Mathematical Bridge Translation",
      "source_domain": "science-of-science",
      "current_trl": 3,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 4,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-scientific-knowledge-overload.yaml"
    },
    {
      "id": "bg-soil-microbiome-engineering",
      "title": "Rational engineering of soil microbiomes for carbon sequestration and crop yield",
      "source_domain": "microbiology",
      "current_trl": 3,
      "world_reshaping_potential": "significant",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-soil-microbiome-engineering.yaml"
    },
    {
      "id": "bg-universal-cancer-early-detection",
      "title": "Liquid biopsy for universal early-stage cancer detection",
      "source_domain": "oncology",
      "current_trl": 4,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-universal-cancer-early-detection.yaml"
    },
    {
      "id": "bg-whole-brain-neural-recording",
      "title": "Whole-brain single-neuron resolution recording in awake behaving mammals",
      "source_domain": "neuroscience",
      "current_trl": 2,
      "world_reshaping_potential": "transformative",
      "blocking_gap_count": 3,
      "required_bridge_count": 3,
      "file": "breakthrough-gaps/bg-whole-brain-neural-recording.yaml"
    },
    {
      "id": "bg-whole-earth-climate-model",
      "title": "Kilometer-scale global climate model for decadal regional prediction",
      "source_domain": "atmospheric-science",
      "current_trl": 3,
      "world_reshaping_potential": "significant",
      "blocking_gap_count": 3,
      "required_bridge_count": 2,
      "file": "breakthrough-gaps/bg-whole-earth-climate-model.yaml"
    }
  ]
}