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Anesthesia

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Open Unknowns

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Cross-Domain Bridges

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Active Hypotheses

Open Unknowns (1)

Unknown What are the specific neural circuit mechanisms by which general anesthetics suppress consciousness — is it primarily thalamo-cortical disconnection, loss of cortical complexity (integrated information), suppression of specific oscillatory modes, or some combination? u-neural-correlates-consciousness-anesthesia-mechanism

Active Hypotheses

Hypothesis The rapid antidepressant effect of ketamine is mediated primarily by the metabolite (2R,6R)-hydroxynorketamine (HNK) acting through AMPA receptor potentiation and BDNF/TrkB signaling, not through NMDA receptor inhibition — implying that non-dissociative AMPA-potentiating agents will reproduce the antidepressant effect without psychotomimetic side effects. high

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