Geroscience

Bridge The glymphatic system — studied separately in sleep medicine, neurology, and geroscience — is a single cross-cutting mechanism linking sleep quality, amyloid clearance, and brain aging rate.

Fields: Sleep Medicine, Neurology, Geroscience, Fluid Dynamics

The glymphatic system (peri-arterial CSF influx driving interstitial waste efflux along paravascular spaces) is studied in three largely separate literatures: sleep medicine (it is most active during ...

Bridge DNA methylation epigenetic clocks are quantitative aging biomarkers that predict chronological and biological age with sub-decade accuracy, bridging epigenetics and geroscience by operationalizing the rate of biological aging.

Fields: Epigenetics, Geroscience, Genomics

Epigenetic clocks (Horvath, Hannum, PhenoAge, GrimAge) use penalized regression on CpG methylation levels across hundreds of genomic loci to construct a quantitative biomarker of biological age that p...