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Neuroscience Glia

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Open Unknowns
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Cross-Domain Bridges
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Active Hypotheses

Open Unknowns (1)

Unknown What determines the threshold between physiological microglial synapse pruning (circuit refinement) and pathological pruning (synaptic loss in Alzheimer's disease) ΓÇâ and can this threshold be pharmacologically modulated to preserve synapses while maintaining immune surveillance? u-microglia-synapse-pruning-alzheimers-pathological-threshold

Active Hypotheses

Hypothesis Complement-mediated microglial synapse pruning (C1q-C3-CR3 pathway) is causally upstream of cognitive decline in Alzheimer's disease ΓÇâ and C1q or C3 inhibition will preserve synapses and slow cognitive decline in clinical trials, independent of amyloid plaque burden. high

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