Search the knowledge catalog
Real-time filter across all unknowns, bridges, hypotheses, and phenomena loaded from the knowledge graph. Press / to focus.
Curated cross-domain engines
Six curated thematic lenses — shortcut entry points into representative bridges in the catalog, not exhaustive domain coverage.
Maintainer playbook (regenerate stats, domain pages, breakthrough cards): docs/DEV_DASHBOARD.md.
Scientific Pioneers
Foundational scientists whose work seeds cross-domain bridges — including underappreciated contributions ripe for rediscovery.
Nikola Tesla
AC power · Wireless energy · Bladeless turbine · Earth-ionosphere resonance
James Clerk Maxwell
Unified electromagnetism · Statistical mechanics · Maxwell's demon
Ludwig Boltzmann
S = k ln W · Arrow of time · Statistical foundations
Emmy Noether
Symmetry → conservation laws · Abstract algebra · Gauge invariance
Claude Shannon
Information entropy · Channel capacity · Boolean circuits
Alan Turing
Turing machine · Halting problem · Morphogenesis reaction-diffusion
Richard Feynman
QED path integrals · Feynman diagrams · Quantum computing pioneer
Barbara McClintock
Transposable elements · Genome plasticity · Epigenetic regulation
Charles Darwin
Natural selection · Common descent · Sexual selection · Earthworm geology
Rosalind Franklin
Photo 51 · DNA X-ray crystallography · Virus structure · Carbon microstructure
John von Neumann
Stored-program computer · Game theory · Quantum formalism · Self-reproducing automata
Albert Einstein
Special & general relativity · Photoelectric effect · Brownian motion · Bose–Einstein condensate
Ada Lovelace
First algorithm · General-purpose computing vision · Analytical Engine programming
Breakthrough Gaps
World-reshaping breakthroughs stalled by cross-domain knowledge gaps. Cards below are generated from the breakthrough-gaps catalog (same YAML CI validates). Click a card to open the source YAML on GitHub; Alt-click (Option-click on macOS) jumps to Catalog search with a prefilled query.
Economically Viable Direct Air Capture of CO2
Direct air capture (DAC) at ~$100/tonne CO₂ (from current $400–1,000/tonne) would make it economically viable to remove atmospheric CO₂ at the gigatonne scale required to meaningfully address climate change. At $100/ton…
Programmable mRNA Therapeutics Beyond COVID Vaccines
The COVID-19 mRNA vaccines (BioNTech/Pfizer, Moderna, 2020–2021) proved the mRNA platform at TRL 9: design-to-manufacture in months, high efficacy, large-scale production. The platform is now being extended to personali…
High-Bandwidth Brain-Computer Interfaces for Restoring and Augmenting Neural Function
High-bandwidth brain-computer interfaces (BCIs) — capable of reading and writing neural activity at the resolution of individual neurons across large brain areas — would enable restoration of motor function in paralysis…
Commercial Fusion Energy — From NIF Ignition to Grid-Scale Power
Nuclear fusion — combining hydrogen isotopes to release energy via E=mc² — offers effectively unlimited, low-carbon electricity with no long-lived nuclear waste and inherent safety (no chain reaction, self-extinguishing…
Liquid biopsy for universal early-stage cancer detection
Detecting any cancer type at stage I from a blood draw — using circulating tumor DNA (ctDNA), cell-free methylation signatures, exosomes, or protein biomarkers — with less than 1% false positive rate and greater than 90…
Low-Temperature Electrochemical Water Splitting for Green Hydrogen
Scalable, low-cost water splitting using earth-abundant catalysts operating near room temperature would make green hydrogen competitive with natural gas reformation, enabling carbon-neutral fuels, long-duration grid sto…
Net energy gain controlled nuclear fusion at commercial scale
In December 2022, the National Ignition Facility achieved Q_fusion > 1 for the first time — the fusion reaction released more energy than the laser energy deposited in the fuel capsule. However, accounting for wall-plug…
Artificial and Enhanced Photosynthesis — Closing the Efficiency Gap from 1-2% to Theoretical Maximum
Natural photosynthesis captures ~1-2% of incident solar energy as chemical energy in biomass — orders of magnitude below the theoretical maximum efficiency (~11% for oxygenic photosynthesis, limited by thermodynamics of…
Cross-Disciplinary Scientific Discovery — Systematic Infrastructure for Cross-Domain Mathematical Bridge Translation
Scientific literature grows at approximately 4% per year, doubling every 17 years. As of 2024, PubMed alone indexes over 37 million articles; the total corpus of peer-reviewed science across all fields exceeds 100 milli…
Disease-Modifying Alzheimer's Therapy — Resolving the Causal Mechanism
Alzheimer's disease (AD) affects 55 million people worldwide and is the leading cause of dementia. After 25 years and >100 failed clinical trials, the amyloid hypothesis (Hardy & Higgins 1992) received partial vindicati…
Fault-Tolerant Quantum Computation at Practical Scale
A fault-tolerant quantum computer with ~1,000 error-corrected logical qubits would break RSA-2048 encryption, simulate quantum chemistry at pharmaceutical-design accuracy (protein folding, drug binding), and solve optim…
Fault-tolerant scalable quantum computing with more than one million logical qubits
Current quantum computers have 1,000-10,000 physical qubits but physical error rates of 0.1-1% per gate, far above the threshold needed for useful computation. Quantum error correction using surface codes requires appro…
Mechanistic understanding and reversal of biological aging
Aging is the largest single risk factor for cancer, heart disease, neurodegeneration, and metabolic disease, yet its mechanism is debated. The leading candidate theories include: epigenetic entropy (information theory o…
New Antibiotic Classes and Alternative Strategies to Overcome Antimicrobial Resistance
Antimicrobial resistance (AMR) is projected to cause 10 million deaths per year by 2050 (O'Neill Review 2016), exceeding cancer mortality. The WHO classifies AMR as one of the top 10 global public health threats. The la…
Rational de novo protein design for arbitrary function
AlphaFold2 and ESMFold solve the forward problem — predicting 3D structure from amino acid sequence — with near-experimental accuracy. The inverse problem remains largely unsolved: designing a novel sequence that will f…
Ambient-Pressure Room-Temperature Superconductivity
A material that superconducts at room temperature and ambient pressure would eliminate resistive losses in electrical grids (~5–10% of generated power), enable compact MRI and fusion magnets without cryogenic infrastruc…
Identifying the neural correlates of consciousness and subjective experience
The hard problem of consciousness — why and how physical processes in the brain give rise to subjective experience (qualia) — has no agreed scientific framework. The easy problems (explaining cognitive functions like at…
Whole-brain single-neuron resolution recording in awake behaving mammals
No technology can simultaneously record all ~86 billion neurons in a human brain at single-neuron resolution during natural behavior. Current state-of-the-art (Neuropixels probes) records roughly 10,000 neurons simultan…
Kilometer-scale global climate model for decadal regional prediction
Current operational global climate models run at 25-100 km horizontal resolution. At this resolution, key processes governing regional climate — mesoscale convective systems, cumulus convection, cloud microphysics, orog…
Neuromorphic computing at scale — brain-matched energy efficiency for AI inference
The human brain performs general-purpose intelligence at approximately 20 watts. Running a 70-billion parameter large language model requires ~70 watts per token generated at the GPU level, and a full inference data cen…
Post-Treatment Lyme Disease Syndrome (PTLDS) — Mechanism and Cure
Borrelia burgdorferi, the Lyme disease spirochete, causes persistent debilitating symptoms in 10–20% of patients even after standard antibiotic treatment. PTLDS (sometimes called chronic Lyme disease) involves fatigue,…
Rational engineering of soil microbiomes for carbon sequestration and crop yield
Soil contains approximately 10^9 microorganisms per gram, representing more than 10,000 species per sample interacting through metabolic exchange, competition, and mutualism in networks too complex to model from first p…
Programmable matter — reconfigurable materials that change shape and function on demand
Materials that can autonomously reconfigure their macroscopic shape, stiffness, and function in response to external commands do not exist beyond proof-of-concept demonstrations at millimeter scale. Shape memory alloys…
Scalable removal and degradation of ocean microplastics
Approximately 170 trillion plastic particles are estimated to be in the ocean, with an additional 8-10 million tons entering annually. Macro-plastic removal by systems such as The Ocean Cleanup is technically feasible b…
Automated knowledge-graph analysis
Three scripts that continuously mine the knowledge graph — surfacing gaps, proposing novel cross-domain connections, and flagging low-quality entries for human review.
Bridge Proposals
Domain pairs with high unknown density and no existing bridge — the most fertile candidates for the next cross-domain discovery.
View proposals ↗Priority Targets
Unknowns with no hypothesis or bridge edge — the highest-impact contribution opportunities in the graph today.
View targets ↗Quality Audit
Automated quality checks across all 401 catalog entries — errors, warnings, and improvement opportunities surfaced automatically.
View audit ↗Hypothesis Generator
Pattern-matching engine that detects which mathematical framework (phase transitions, information theory, scaling laws) best connects two domains, then drafts bridge YAMLs for expert review.
How it works →Citation Index
Papers cited across multiple bridges — the most cross-domain influential works in the scientific literature. Shannon, Turing, Fisher, and their equivalents.
View index →Static JSON endpoints
No authentication. No rate limits. Served directly from GitHub Pages.
Base URL: https://kr8zysho3.github.io/Universal-Science-Discovery/api/v1/
GET /api/v1/meta.json
Catalog statistics, counts, and metadata
~1 KB
GET /api/v1/bridges.json
All 1123 cross-domain bridges with translation tables and references
~213 KB
GET /api/v1/unknowns.json
All 1408 open unknowns with domain, status, and file path
~451 KB
GET /api/v1/hypotheses.json
All 1274 hypotheses with priority, impact score, and evidence links
~114 KB
GET /api/v1/breakthrough_gaps.json
24 breakthrough-gap summaries (TRL, potential, blocking / required-bridge counts)
~8 KB
GET /api/v1/domains.json
Per-domain summary statistics (unknowns and bridge counts)
~2 KB
GET /api/v1/graph.json
Full knowledge graph — 3857 nodes, 4517 edges (built from catalog YAML; mirrors docs/knowledge_graph.json)
~578 KB
GET /api/v1/bridge_proposals.json
AI co-pilot bridge proposals ranked by novelty score
~6 KB
Cross-domain connection map
Force-directed graph of the full catalog — bridges, unknowns, hypotheses, and phenomena (counts update live when the JSON loads). Hover a node to inspect it. Click a node for full details. Drag to reposition. Scroll or pinch to zoom.
New here? Follow this order
Same path as CONTRIBUTING.md and docs/ONBOARDING.md, laid out as steps. Clone the repo so file links open directly in your editor.
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Know what you're joining
Vision, motivation, and why this infrastructure matters for science.
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Scope and quality bar
What lives here, what doesn't, and the rigor expected of every entry.
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Rigor: hypotheses vs. findings
The evidence bar, claims discipline, and output conventions. Read before proposing any scientific claims.
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Integrity, data, and conduct
Ethics policy, what data may be committed, and community norms.
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Make your first contribution
Stream A: validate setup → add a
u-…unknown → add ah-…hypothesis → open PR.
Pick a workstream, own it
Development is divided into independent areas. Find one that fits your skills, comment on an open issue to claim it, and open a draft PR early. Full details: WORKSTREAMS.md.
status:needs-owner. Comment "I'm taking this." A maintainer assigns it to you.feat/<area>/<slug> from main. Open a draft PR immediately to signal what you are working on.main is branch-protected — no direct pushes.Phase 1 — Discovery & adoption (2026–2027)
Phase 0 — Foundation is complete (governance, schemas, CI, catalog seed, graph, hub). Below are calendar- and community-dependent milestones; development and catalog growth continue in parallel.
Milestone progress
Active0 / 7 Phase 1 milestones complete
Ring = completed Phase 1 items only. In-progress items still appear in the checklist below.
Recent commits
All commits ↗CI Pipelines
Actions ↗Where to add knowledge
Start with HAPPY_PATH_FIRST_RECORDS.md — the guided walk from zero to your first unknown + hypothesis PR.
Stream A — first records
Step-by-step: validate setup → add u-… unknown → add h-… hypothesis → open PR.
Unknowns catalog
Research gaps tracked as u-… YAML files under unknowns-catalog/.
Hypotheses
Testable proposals as h-… YAML with evidence links and falsification criteria.
Cross-domain bridges
Explicit connections between fields studying the same phenomenon — the anti-tunnel-vision layer. Schema: b-… YAML.
Schemas & templates
YAML schemas for validation and PR/issue templates for structured contributions.
Contribution guide
Rules of the road, AI use policy, and ingest integration notes.
AI assistants (Cursor)
If you use Cursor or other agents — rules and agent-specific policy.
Understand the architecture
Vision, roadmap, system architecture, and outreach framing.
Repo entry & narrative
Default landing for new visitors; overview of all major areas.
Roadmap & phases
North-star vision through 2035, phase milestones, and guiding principles.
System architecture
Discovery Core, Human Layer, AI Layer, and the Integration & Data Layer.
Outreach framing
Accurate language for external conversations and contributor recruiting.
Trust, licensing, and how we run it
Governance, legal framework, conduct, and the quality bar that makes contributions credible.
Legal & licensing
What the repo may host; third-party attribution and IP policy.
Governance & ethics
Decision-making structure, ethics framework, and integrity requirements.
Quality bar
CI gates, review lanes, definition of done — the anti-sloppiness playbook.
Collaboration & reviews
Review expectations, issue labels, and working group norms.
Cadence & operations
Branch protection, CI gates, and the daily operating rhythm.
Maps & traceability
From "this file" to "what policy it enforces" — audit trails and the full onboarding path.
Data & ingestion (technical)
Phase A/B metadata plans, ingest envelope schema, and example data.
Live checklist & roadmap
Doc discipline: at each milestone or feature merge, update README,
CHANGELOG (Unreleased), relevant docs/, and this hub if links change. ·
Pull requests ·
Open issues ·
CHANGELOG.md